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The journal seeks to publish, on an annual basis, quality works that focus on experiences in medicine and expressions of the human condition. 

Submissions of creative works of poetry, art, photography, fiction and non-fiction, including narrative and reflections, to Synapses are open to faculty, staff, students, residents, fellows and alumni of Chicago Medical School. 

Each submission is reviewed blindly at two levels: first by reviewers, followed by editors. Authors will be notified of editorial decisions. Submissions will open in October and close in January. The journal will be published once per year in the spring.